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Antidiabetic Activity of the Methanolic Extracts of Thuja occidentalis Twings in Alloxan-induced Rats

[ Vol. 5 , Issue. 2 ]

Author(s):

C. K. Tyagi, Pawan Porwal, Neeraj Mishra, Amit Sharma, A. Chandekar, R. Punekar, V. T. Punniyakoyi, Ajay Kumar and Durgadas Anghore*   Pages 126 - 131 ( 6 )

Abstract:


Objective and Background: In hyperglycemic and alloxan-induced diabetic rats, the effect of Thuja occidentalis methanolic residue extract on blood glucose levels and some biochemical parameters were investigated.

Methods: Significantly decreased blood glucose level by 22.85 %and 27.66 %, in hyperglycemic rats, respectively after 3 h, were seen in a single oral administration of the extract at a dose of 200 and 400 mg/kg. Blood glucose level was decreased by 50% in alloxan-induced diabetic rats within three weeks of daily treatment of Thuja occidentalis methanolic residue extract (200 and 400 mg/kg p.o). Alloxan-induced diabetic rats showed significant hypercholesterolemia in comparison with the control in alloxan induced rats.

Results and Conclusion: In both normal and diabetic rats, there was also a significant decrease of elevated serum cholesterol and triglycerides. Hypertriglyceridemia was also shown to be prevented by treatment with plant extract (200 and 400mg/kg p.o) (p<0. 05). As compared with the control animals, diabetic control rats did not show any change in a level of creatinine and urea. Thuja occidentalis treatment may improve glucose homeostasis in alloxan- induced diabetes and ameliorate kidney and liver functions. Thuja occidentalis treatment may improve glucose homeostasis in alloxan-induced diabetes and alleviate kidney and liver function. Thuja occidentalis twigs could be a potential source of the new oral antidiabetic drug.

Keywords:

Thuja occidentalis, diabetes, alloxan, hyperglycemic activity, methanolic extracts, triglycerides.

Affiliation:

Department of Pharmacology, RKDF College of Pharmacy, Bhopal, Amity School of Pharmacy, Gwalior, MP, ISF College of Pharmacy, Moga, Punjab, ISF College of Pharmacy, Moga, Punjab, Department of Pharmacology, RKDF College of Pharmacy, Bhopal, Department of Pharmacology, RKDF College of Pharmacy, Bhopal, ISF College of Pharmacy, Moga, Punjab, ISF College of Pharmacy, Moga, Punjab, ISF College of Pharmacy, Moga, Punjab



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