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Naringenin Scaffold as a Template for Drug Designing

Author(s):

Yogesh Murti*, Bhupesh Chander Semwal, Ahsas Goyal and Pradeep Mishra   Pages 1 - 17 ( 17 )

Abstract:


Natural products provides cornucopia of heterocyclic systems. 2-Phenyl chromane nucleus is one of the important and well known heterocycles present in natural products. Naringenin, a plant-derived flavanone (2-phenyl chroman-4-one) belongs to the family of flavanoids. It possesses diverse biologic activities such as antidiabetic, antiatherogenic, antidepressant, antiandrogenic, antiestrogenic, immunomodulatory, antitumor, antimicrobial, anti-inflammatory, antiviral, hypolipidemic, antihypertensive, antioxidant, neuroprotective, anti-obesity, anti-Alzheimer, and memory enhancer activity. It has potential to be used as an active pharmacophore. A number of molecular mechanisms underlying its beneficial activities have been reported. With emerging interest in the traditional medicine and exploit their potentials based on different health care system, it was thought to explore literature on naringenin. Further, this review aims to provide newer insights of naringenin and its derivatives as lead compound in drug design to a new era of flavonoid based therapeutic agents.

Keywords:

Naringenin, flavanone, pharmacophore, drug desigNaringenin, drug design

Affiliation:

Institute of Pharmaceutical Research, GLA University, Mathura N.H.#2, Mathura-Delhi Road, P.O. Chaumuhan, Mathura-281 406, Institute of Pharmaceutical Research, GLA University, Mathura N.H.#2, Mathura-Delhi Road, P.O. Chaumuhan, Mathura-281 406, Institute of Pharmaceutical Research, GLA University, Mathura N.H.#2, Mathura-Delhi Road, P.O. Chaumuhan, Mathura-281 406, Institute of Pharmaceutical Research, GLA University, Mathura N.H.#2, Mathura-Delhi Road, P.O. Chaumuhan, Mathura-281 406



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