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Sophoricoside: Bioactive Compounds from Sophora japonica, their Role in Disease Prevention and Treatment

Author(s):

Kanika Patel, Gulam Mohammad Husian, Devendra Kumar Katiyar, Satyendra K Prasad and Dinesh Kumar Patel*   Pages 1 - 9 ( 9 )

Abstract:


Herbal drugs and their derived products play an important role in the human life due to their defensive nature against various diseases. Demand of herbal based products is continuously increasing in the society due to their less toxicity and more health value. Pure phytochemicals of plants have been placed in the modern medicine due to their health promoting aspects as we know that some of the important modern medicines contain pure active chemicals obtained from plants, minerals and organic matter. A large number of drugs prescribed in the modern medicine are derived from plants. Phytochemicals are present in various herbs, fruits, vegetables, oil, and seeds. Sophora japonica is a tree native to China and Korea also called Japanese pagoda tree or Chinese scholar tree. Sophoricoside is an isoflavone glycoside present in the Sophora japonica plant. Sophoricoside has been known for its estrogenic activity, anti-inflammatory, anti-oxidant, anti-diabetic and immunomodulatory activity. In the present review paper, we have collected all the information of sophoricoside and summarized their pharmacological activities, pharmacokinetic, analytical techniques and biotransformation method in very concise manner. This article aims is to provide an overview of the pharmacological effects of sophoricoside and their mechanisms of actions in various diseases. Databases namely Medline, PubMed, Google and Science direct were searched to collect the data for this review. The present review will be helpful to the scientists of Botanical, Medicinal and Pharmaceutical field for discovery and development of new novel medicines from sophoricoside.

Keywords:

Analytical method, Herbal drug, Pharmacological activities, Phytoconstituents, Sophora japonica, Sophoricoside

Affiliation:

Department of Pharmaceutical Sciences, Faculty of Health Science, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences Naini, Prayagraj, 211007, Uttar Pradesh, Department of Pharmacology, Department of Ayush, Hyderabad, India, Tilak Road, Abids, Hyderabad, Telangana 500001, Department of Pharmacology, Department of Ayush, Hyderabad, India, Tilak Road, Abids, Hyderabad, Telangana 500001, Department of Pharmaceutical sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Maharashtra, Department of Pharmaceutical Sciences, Faculty of Health Science, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences Naini, Prayagraj, 211007, Uttar Pradesh



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