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Biochemical and Pharmaceutic Properties of Genus Phyllanthus spp.: Focus on P. amarus Schum. & Thonn. and P. niruri L.

Author(s):

Maria Francilene Souza Silva*, Fátima de Cássia E. de Oliveira, Maria Claudia dos Santos Luciano, Guilherme J. Zocolo and Claudia Pessoa   Pages 1 - 19 ( 19 )

Abstract:


The genus Phyllanthus belongs to the family Phyllanthaceae with large global distribution, with about 833 species, including Phyllanthus amarus and P. niruri. These species are widely used in traditional medicine because of their pharmacological potential. The objective of this work is to measure the potential of genus Phyllanthus after a technological and scientific monitoring to quantify and evaluate publications and patents related to Phyllanthus spp. with emphasis on P. amarus and P. niruri. The scientific monitoring summarizes morphotaxonomic, pharmacological, chemical, ethnomedicinal and biological aspects. The research was carried out based on papers found in journals deposited in the Web of Science and NCBI (PUBMED) databases and on patents found in the European Patent Office (ESPACENET), Google Patents and the National Institute of Industrial Property (INPI). The results show strong interest in the areas of Pharmacology and Medicinal Chemistry. Patents fall within the Human Necessities section by International Patent Classification as preparations for Medical, Dental or Hygienic Purposes. The summary of monitoring analysis demonstrates the potential pharmacological potential of P. amarus and P. niruri as agents to treat different types of diseases and a range of possibilities for clinical trials in several areas of health.

Keywords:

Pharmacology, Phytopharmaceutical, Prospection, “quebra-pedra”, Kidney-stone, Medicinal

Affiliation:

Federal University of Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos-NPDM, Rua Coronel Nunes de Mello 1000, CEP 60420-275, Fortaleza, CE, Federal University of Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos-NPDM, Rua Coronel Nunes de Mello 1000, CEP 60420-275, Fortaleza, CE, Federal University of Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos-NPDM, Rua Coronel Nunes de Mello 1000, CEP 60420-275, Fortaleza, CE, Federal University of Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos-NPDM, Rua Coronel Nunes de Mello 1000, CEP 60420-275, Fortaleza, CE, Federal University of Ceará, Núcleo de Pesquisa e Desenvolvimento de Medicamentos-NPDM, Rua Coronel Nunes de Mello 1000, CEP 60420-275, Fortaleza, CE



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