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The Effects of the “XGTQ” Medicine in Treating Cirrhosis in Wistar Rats

[ Vol. 7 , Issue. 3 ]

Author(s):

Ngan Nguyen Hoang , Thang Duong Minh, Tuan Anh Hoang, Son Le Ngoc Bich, Duong Nguyen Huu, Xuan Thanh Nguyen, Binh Nhu Do and Tuan Nguyen Thanh Ha*   Pages 438 - 444 ( 7 )

Abstract:


Objectives: To evaluate the effects of “XGTQ” in the treatment of cirrhosis induced by Carbon tetrachloride (CCL4) in combination with alcohol and a high-fat diet on Wistar rats.

Materials and methods: Cirrhosis on white rats was induced by subcutaneously injecting CC14 at an initial dose of 5,0ml/kg, followed by 1,2ml/kg once a week in 10 weeks. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered every day with plain water and 1 day with water mixed with 30% ethanol. The rats were randomly divided into 5 groups and given distilled water (group 1 and 2 or control group), silymarin (group 3 or reference group) or the “XGTQ” drug extract (group 4, 5) for 4 weeks. Collected blood for biochemical test and liver were dissected to evaluate weight, morphology, and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation.

Results: In cirrhotic Wistar rats, “XGTQ” drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability toreduce the activity of enzymes AST, ALT in the blood (p<0.01), increasing plasma albumin and decreasing prothrombin time (p<0.05); improving physical condition, macroscopic and microscopic images of H&E-stained liver; decreasing the concentration of hydroxyproline in the liver and reducing the level of cirrhosis on the Masson-stained templates. The effects of “XGTQ” increased with the dose and was equivalent to silymarin at the dose of 70 mg/kg/24h.

Conclusion: The extract of “XGTQ” drug is effective in treating cirrhosis in Wistar rats.

Keywords:

XGTQ, cirrhosis, wistar rats, CCl4, silymarin.

Affiliation:

Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi, Military Central Hospital 108, No.1 Tran Hung Dao st, Hoan Kiem, Hanoi, Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi, Tianjin University of Medicine and Pharmacy, No.22 Qixiangtai Rd, Heping, Tianjin, Military Institute of Traditional Medicine, No.442 Kim Giang st, Hoang Mai, Ha noi, Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi, Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi, Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi



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